Intrexon Collaborators Obtain Access to Premier Pipeline of Large Animal Research Models and Custom Animal Development
Mattawan, Mich. and Sioux Center, Iowa (Aug. 27, 2015) : MPI Research and Exemplar Genetics today announced the first successful validation of a new genetically engineered miniature pig model, offering an attractive alternative to rodent models, of atherosclerosis. The ExeGen® LDLR miniswine is a pig model in which the LDL receptor (LDLR) gene is knocked out, resulting in a more accurate analogue to atherosclerosis in humans, providing increased value to human clinical trials.
Using a unique animal model of cystic fibrosis, a team of scientists from the University of Iowa has discovered a difference between healthy airways and airways affected by cystic fibrosis that leads to reduced bacterial killing in cystic fibrosis airways.The human airway is a pretty inhospitable place for microbes. There are numerous immune defense mechanisms poised to kill or remove inhaled bacteria before they can cause problems.
The three litters of Yucatan miniature piglets, born in late May, dwell in a space more like a neonatal care unit than a barn. They require hand-feeding and frequent veterinary attention from the staff at Exemplar Genetics in Sioux Center, Iowa. Their muscles already show the signs of deterioration that they were bred for.