Publications


ATM

  1. Genetic ataxia telangiectasia porcine model pheno copies the multisystemic features of the human disease
    November 2017
  2. A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease
    November 2015

LDLR

  1. H19 Induces Abdominal Aortic Aneurysm Development and Progression
    April 18, 2018
  2. Bempedoic Acid Lowers Low-Density Lipoprotein Cholesterol and Attenuates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR+/- and LDLR-/-) Yucatan Miniature Pigs

    February 15, 2018
  3. A Translational Model for Diet-Related Atherosclerosis: Effect of Statins on Hypercholesterolemia and Atherosclerosis in a Minipig

    February 16, 2016
  4. Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
    April 2014

CFTR

  1. Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs

    September 2017
  2. Postnatal Airway Growth in Cystic Fibrosis Piglets

    June 2017
  3. Monocyte Derived Macrophages From CF Pigs Exhibit Increased Inflammatory Responses at Birth
    
April 2017
  4. Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus

    October 2016
  5. Cystic Fibrosis News Today- Pig Model of Cystic Fibrosis Seen to Aid in Development of Gene Therapies
    September 2016
  6. Lentiviral-Mediated Phenotypic Correction of Cystic Fibrosis Pigs

    September 28, 2016
  7. CFTR Gene Transfer with AAV Improves Early Cystic Fibrosis Pig Phenotypes
    September 8, 2016
  8. Repurposing Tromethamine as Inhaled Therapy to Treat CF Airway Disease
    June 2, 2016
  9. Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus
    
March 2016
  10. Supplementary Material for Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
    
February 2016
  11. Electrolyte Transport Properties in Distal Small Airways From Cystic Fibrosis Pigs With Implications for Host Defense

    January 2016
  12. Discovering a Molecular Basis for Airway Smooth Muscle Dysfunction Through Genome Wide Transcriptional Analysis in the CF Pig

    October 2015
  13. Using Newborn CF and Non-CF Pigs to Assess Airway Mucus

    October 2015
  14. Calprotectin Expression is Constitutively Altered in the CF Pig at Birth Prior to the Onset of Neutrophil-Mediated Inflammation

    October 2015
  15. Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans

    October 2015
  16. Lentiviral Vector-Mediated CFTR Gene Transfer to CF Pig Airways Corrects the Anion Transport Defect In Vivo
    
May 2015
  17. CFTR Expression Contributes to Fluid Secretion and is Induced By FGF10 in Fetal Pig Lung
    
September 2014
  18. Airway Mucus and Early Evidence of Gas Trapping in the CF Pig
    
September 2014
  19. Impaired Mucus Detachment Disrupts Mucociliary Transport in Newborn Pigs Lacking CFTR Anion Channels

    September 2014
  20. Impaired Mucus Detachment Disrupts Mucociliary Transport in a Piglet Model of Cystic Fibrosis
    
August 2014
  21. Glycemic Regulation and Insulin Secretion Are Abnormal in Cystic Fibrosis Pigs Despite Sparing of Islet Cell Mass

    August 2014
  22. Porcine Nasal Epithelial Cultures for Studies of Cystic Fibrosis Sinusitis.

    April 14, 2014
  23. Abundance of DNase-Susceptible Bacterial DNA from Damaged Cells in the Lungs of Pigs
    
January 2014
  24. Assessing Mucociliary Transport of Single Particles in Vivo Shows Variable Speed and Preference for the Ventral Trachea in Newborn Pigs
    
January 2014
  25. Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition
    
December 2013
  26. A Novel Gene Delivery Method Transduces Porcine Pancreatic Duct Epithelial Cells.
    
November 20, 2013
  27. Genotype-Specific Alterations in Vascular Smooth Muscle Cell Function in Cystic Fibrosis Piglets.
    
October 21, 2013
  28. Immunohistochemical Expression of MUC5B in Human and Porcine Airways
    
October 2013
  29. Mucociliary Transport in Newborn CF and Non-CF Pigs
    
October 2013
  30. Reduced PH Increases Viscosity of Porcine Cystic Fibrosis Airway Surface Liquid

    October 2013
  31. Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets

    October 2013
  32. Acute Inflammatory Responses to Bacterial Challenge in Newborn CF and Non-CF Pigs

    October 2013
  33. Expression and Localization of Porcine Airway Mucins

    October 2013
  34. Air Trapping Occurs Prior to the Onset of Airway Infection, Inflammation, and Mucus Obstruction in CF Pigs
    
October 2013
  35. Abundant DNase I Sensitive Bacterial DNA in Healthy Porcine Lungs: Implications for the Lung Microbiome.

    July 2013
  36. Intestinal CFTR Expression Alleviates Meconium Ileus in Cystic Fibrosis Pigs

    May 2013
  37. Adenoviral Gene Transfer Corrects the Ion Transport Defect in the Sinus Epithelia of a Porcine CF Model. BAD LINK

    March 19, 2013
  38. CFTR-Deficient Pigs Display Peripheral Nervous System Defects at Birth. BAD LINK
    
February 4, 2013
  39. Interleukin-13 Induces Comparable Goblet Cell Hyperplasia in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cultures
    
September 2012
  40. Understanding the CF Airway Surface With the CF Pig

    September 2012
  41. Abnormal Regulation of Airway Smooth Muscle Function in Newborn Cystic Fibrosis Pigs
    
September 2012
  42. Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis

    September 2012
  43. Computer-Aided Analysis of Airway Trees in Micro-CT Scans of Ex-Vivo Porcine Lung Tissue

    September 2012
  44. Pancreatic and Biliary Secretion Are Both Altered in Cystic Fibrosis Pigs
    
August 30, 2012
  45. Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung.
    
July 4, 2012
  46. Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis.
    September, 2012
  47. Pancreatic Damage in Fetal and Newborn Cystic Fibrosis Pigs Involves the Activation of Inflammatory and Remodeling Pathways.
    June 8, 2012
  48. The Cytokines Interleukin-1β and Tumor Necrosis Factor-α Stimulate CFTR-Mediated Fluid Secretion by Swine Airway Submucosal Glands.
    
June 8, 2012
  49. CFTR is Required for Maximal Transepithelial Liquid Transport in Pig Alveolar Epithelia.
    
May 25, 2012
  50. Cystic Fibrosis Pigs Have Altered Airway Smooth Muscle Function At Birth

    May 2012
  51. Intestinal Expression of CFTR Alleviates the Meconium Ileus Phenotype in Cystic Fibrosis Pigs

    April 2012
  52. Requirements for Ion and Solute Transport, and pH Regulation During Enamel Maturation.
    
April 2012
  53. Chloride Secretion by Cultures of Pig Tracheal Gland Cells.
    
February 24, 2012
  54. Properties of Substance P-Stimulated Mucus Secretion From Porcine Tracheal Submucosal Glands.
    December 23, 2011
  55. New Animal Models of Cystic Fibrosis: What Are They Teaching Us?
    November 17, 2011
  56. An Activated Immune and Inflammatory Response Targets the Pancreas of Newborn Pigs With Cystic Fibrosis.
    November 1, 2011
  57. Intestinal Expression of CFTR Alleviates the Meconium Ileus Phenotype in Cystic Fibrosis Pigs

    November 2011
  58. Endogenous Surface Expression of ΔF508-CFTR Mediates cAMP-Stimulated Cl(-) Current in CFTR(ΔF508/ΔF508) Pig Thyroid Epithelial Cells.
    September 23, 2011
  59. Defective Fluid Secretion From Submucosal Glands of Nasal Turbinates From CFTR-/- and CFTR (ΔF508/ΔF508) Pigs. BAD LINK 

    August 31, 2011
  60. Human Cystic Fibrosis Airway Epithelia Have Reduced Cl- Conductance But Not Increased Na+ Conductance.
    June 21, 2011
  61. Swine Models of Cystic Fibrosis Reveal Male Reproductive Tract Phenotype at Birth. BAD LINK
    
May 18, 2011
  62. Concentration of the Antibacterial Precursor Thiocyanate in Cystic Fibrosis Airway Secretions.
    February 18, 2011
  63. Sinus Disease in CFTR-/- Pigs
    
January 2011
  64. Absence of CFTR Disrupts Airway Smooth Muscle Function in a Porcine Model of Cystic Fibrosis

    January 2011
  65. Morphometric Analysis of Exocrine Pig Pancreas Suggests A Sequential Pathogenesis for Fetal CF Pancreas Disease
    
January 2011
  66. Production of Antimicrobial Peptides is Preserved in the Airways of Pigs With Cystic Fibrosis
    
January 2011
  67. Newborn Cystic Fibrosis Pig Tracheal Lobe Airway Diameter and Compliance Measured With Micro-CT

    January 2011
  68. What Do New Animal Models Teach Us About Lung Infections in CF?

    January 2011
  69. Cystic Fibrosis: An-Ion Transport Issue?
    
February 17, 2011
  70. The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
    
March 16, 2011
  71. Enamel Pathology Resulting From Loss of Function in the Cystic Fibrosis Transmembrane Conductance Regulator in a Porcine Animal Model.
    
April 28, 2011
  72. Pancreatic and Biliary Secretion Differ in Cystic Fibrosis and Wild-Type Pigs
    
June 2011
  73. Efficient Production of Fah-Null Heterozygote Pigs By Chimeric Adeno-Associated Virus-Mediated Gene Knockout and Somatic Cell Nuclear Transfer.

    August 9, 2011
  74. Altered Ion Transport By Thyroid Epithelia From CFTR(-/-) Pigs Suggests Mechanisms For Hypothyroidism in Cystic Fibrosis.
    December 2010
  75. Thyroid Glands From Pigs With Cystic Fibrosis, Old Issues, New Ways.
    December 2010
  76. Loss of Anion Transport Without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia.
    December 10, 2010
  77. Pigs and Humans With Cystic Fibrosis Have Reduced Insulin-Like Growth Factor 1 (IGF1) Levels at Birth.
    
November 23, 2010
  78. Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
    
November 2010
  79. Hyposecretion of Fluid From Tracheal Submucosal Glands of CFTR-Deficient Pigs.
    September 2010
  80. Transgenic Animals May Help Resolve a Sticky Situation in Cystic Fibrosis.
    
September 2010
  81. cAMP-Activated Ca2+ Signaling is Required for CFTR-Mediated Serous Cell Fluid Secretion in Porcine and Human Airways.
    September 2010
  82. Role of CFTR on Sinus Development and Disease in the CF Pig
    
August 2010
  83. Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children.
    
July 9, 2010
  84. Transepithelial Electrolyte And Fluid Transport In Type II Alveolar Epithelia In A Porcine Model Of Cystic Fibrosis
    
May 2010
  85. Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.
    April 28, 2010
  86. Pathology of Gastrointestinal Organs in a Porcine Model of Cystic Fibrosis

    March 2010
  87. Investigation of the Craniofacial and Dental Phenotype in the CFTR-Targeted Pig
    
January 2010
  88. Pathology of Gastrointestinal Organs in a Porcine Model of Cystic Fibrosis.
    January 28, 2010
  89. Tracheal Abnormalities Are Present in CFTR-/- Neonatal Pigs and Young Children With CF

    January 2010
  90. Transepithelial Electrolyte Transport By Airway Epithelia in a Porcine Model of Cystic Fibrosis

    January 2009
  91. Hyposecretion of Mucus From Airway Submucosal Glands of CF Piglets
    
January 2009
  92. Mucus Hyposecretion From Submucosal Glands From Nasal Turbinate of CF Piglets
    
January 2009
  93. Development of a Porcine Model of Cystic Fibrosis.
    
2009
  94. Production of CFTR-Null and CFTR-ΔF508 Heterozygous Pigs by Adeno-Associated Virus - Mediated Gene Targeting and Somatic Cell Nuclear Transfer

    May 2008